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. 2023 Jan 17;13:1017076. doi: 10.3389/fimmu.2022.1017076

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Copyright © 2023 Reinehr, Girbig, Schulte, Theile, Asaad, Fuchshofer, Dick and Joachim

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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No microglia activation in CTGF+ONA optic nerves (A) Microglia/macrophages were labelled with anti-Iba1 (red) and microglia with double staining with anti-Tmem119 (green). DAPI counterstained cell nuclei (blue). (B) The number of Iba1⁺ cells was not different within all groups. (C) Also, no changes were observed in the number of Tmem119⁺ and Iba1⁺ double positive cells within all groups. (D) The mRNA expression levels of Iba1 were not altered in WT+ONA and CTGF optic nerves, while a significant upregulation was noted in the CTGF+ONA group. (E) Tmem119 mRNA expression levels were equivalent in all groups. Values are mean ± SEM for immunohistology and median ± quartile ± minimum/maximum for RT-qPCR. The dotted lines in (D, E) represent the relative expression of the WT group. **p<0.001 vs. WT. Scale bars: 20 µm.