TABLE 2.

Resistance to >500/μl and febrile parasitemia for >2 months following a parasitemia genotyped for MSP-1 Block2 alleles^a

Variable	Variable level	Resist >2 mo (%)	Adjusted EE RR vs Ref.	N Obs. (part)	95% CI of EE	P vs Ref.
RO parasite	Present	19.84	3.46	535	1.6–7.3	0.0012
	Absent	13.04	1.00	119
COIKM (count)	0	50.00	26.61	16	7.1–100.0	0.0000
	1	38.78	15.21	74	5.6–41.5	0.0000
	2	33.06	8.96	155	3.3–24.1	0.0000
	3	17.73	4.63	165	1.6–13.1	0.0039
	4	10.09	2.19	122	0.7–6.9	0.1804
	≥5	3.67		121
Village EIR	Low	22.73	NT	187
	Medium	20.47		367
	High	8.99		99
Post-paras EIR exposure	High	21.44	2.88	175	1.7–3.9	0.0001
	Hyper	13.94	1.00	479
Treatment	Yes	23.08	NT	196
	No	17.72		458
Fever ≥37.5°C	Yes	25.81	2.98	272	1.8–3.0	0.0079
	No	15.00	1.00	382
Paras within 1 mo prior to this paras	COIKM ≥5	12.20	NT	41
	COIKM 4	13.16		38
	COIKM 3	12.96		54
	COIKM 2	22.03		59
	COIKM 0–1	21.88		32
	Tx COIKM 0–9	20.73		81
	Aparasitemic	17.39		46
Fever within 1 mo prior	Yes	17.95	NT	127
	No	16.00		288
Age (yr)	0.00–0.49	41.77	15.24	89	4.8–48.9	0.0000
	0.50–0.99	19.65	3.74	155	1.2–11.7	0.0234
	1.00–1.49	18.32	4.93	138	1.5–15.9	0.0078
	1.50–1.99	14.69	3.82	184	1.5–9.7	0.0048
	2.00–3.00	7.32	1.00	89
Parasite density (n/μl)	1–500	33.75	NT	124
	501–2,500	16.55		141
	2,501–5,000	18.18		88
	5,001–10,000	10.89		101
	10,001–25,000	19.01		121
	25,001–86,907	23.35		71
Sickle cell gentoype	SS	52.00	5.05	27 (4)	2.0–12.9	0.0007
	AS	23.70	1.82	141 (13)	1.0–3.2	0.0427
	AA	15.98	1.00	473 (43)		0.0000
Sex	Female	19.78	NT	325 (29)
	Male	19.21		329 (31)
Species detected by m.scopy	Pm and Po	15.38	NT	13
	Pf-Po-Pm	12.50		40
	Pf only	18.71		601

^aGLM controlled for repeated measurements on individuals and did not include genotyped samples within a resist >2 mo interval. Variables showing NT (P > 0.1) were removed. The univariate percent is shown. The EE is expressed as the adjusted relative risk (RR) relative to the Ref. (set to RR = 1). See Table 1 for abbreviations.