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. 2022 May 2;206(2):186–196. doi: 10.1164/rccm.202110-2309OC

Figure 3.

Figure 3.

Global Uty-KO promotes more severe PH, which is prevented by KD of Cxcl9 and Cxcl10. (A) Experimental protocol: 30 days after GDX, age-matched global Uty-KO or WT male mice receive scramble siRNA or siRNA targeting Cxcl9 and Cxcl10 genes every 3–5 days and are placed in Hx for 3 weeks. (B) RVSP measured by direct RV catheterization. (C) PAAT measured by echocardiography. (D) Fulton index (RV/LV + IVS). (E) Quantification of Cxcl9 and Cxcl10 transcripts in whole lung tissue by means of real-time qPCR (normalized to Si-Scrm). *P < 0.05 and ***P < 0.001. GDX = gonadectomy; HX = hypoxia; IVS = intraventricular septum; KD = knockdown; KO = knockout; LV = left ventricle; ns = not significant; PAAT = pulmonary artery acceleration time; PH = pulmonary hypertension; RV = right ventricle; RVSP = right ventricular systolic pressure; WT = wild type.