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. Author manuscript; available in PMC: 2023 Jan 31.
Published in final edited form as: Chem Res Toxicol. 2020 Dec 21;34(2):495–506. doi: 10.1021/acs.chemrestox.0c00322

Table 3:

Description of four toxicity properties used for augmentation.

Category Property Description
Toxicity herg32,33 measures cardiotoxic effects of compounds.
PLD28 stands for phospholipidosis, which measures organism-level toxicity of compounds.
ames34,35 measures mutagenicity, one of the most important end points of toxicity.
mmp36,37 The mitochondrial membrane potential (MMP) is a key parameter for evaluating mitochondrial function.