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. 2022 Dec 21;86(1):8–17. doi: 10.1021/acs.jnatprod.2c00481

Figure 1.

Figure 1

Flowchart describing the processing steps starting from four M. alba plant parts toward the hit extract selection (PLE, pressurized liquid extraction; SFE, supercritical fluid extraction; TE, traditional extraction; *tested at 10 μg/mL). Initially, all four plant parts were extracted with SFE and TE for biocompatibility reasons. As the root bark was the only plant part to contain MDAAs, PLE additionally was applied to further increase the total MDAA content.