Table 2. MIC of Cyclotides Extracted against E. coli, P. aeruginosa, S. aureus, and C. albicans and Cytotoxic Activity in the FMCA Using the Human Lymphoma Cell Line U-937 GTB.
| antimicrobial
activity, MIC (μM) |
cytotoxicity, IC50 (μM) | ||||
|---|---|---|---|---|---|
| cyclotide | Escherichia coli | Pseudomonas aeruginosa | Staphylococcus aureus | Candida albicans | lymphoma U937 |
| gere 1 | 4.0 | 7.9 | >10 | >10 | 2.0 |
| gere 2 | >10 | >10 | >10 | >10 | 6.1 |
| gere 3 | >10 | >10 | >10 | >10 | 2.2 |
| gere 4 | >10 | >10 | >10 | >10 | 2.6 |
| kB7 | >10 | >10 | >10 | >10 | >10 |
| cyO2a | >10 | 10 | >10 | >10 | 0.26–1.8 |
| kB7a | >10 | 1.25 | >10 | >10 | >10 |