Figure 1.

Trends in the rates of severe hypoglycemic and hyperglycemic events among people with type 1 diabetes (A) and type 2 diabetes (B) from 2011 to 2020. Rates of severe hypoglycemia and hyperglycemia were calculated as marginal probabilities using logistic regression models (individual models for type 1 and type 2 diabetes for each outcome of severe hypoglycemia and hyperglycemia), adjusted for patient age, sex, race, ethnicity, and U.S. region. P values assess trends in event rates over time, with the null hypothesis of no change over time. Coding methodology for severe hypoglycemia and hyperglycemia changed between 2015 and 2016 due to transition from ICD-9 to ICD-10 codes, affecting hypoglycemia ascertainment more than severe hyperglycemia due to greater availability of hypoglycemia ICD-10 codes than ICD-9 codes.