Table 2.

Probability of a complication occurring within the next 5 years from a specific time point from DCCT randomization for individuals without and with a prior complication by time t^†

Outcome in the next 5 years	Time (years)	Prior PDR (%)		Prior CSME (%)		Prior reduced eGFR (%)		Prior amputation (%)		Prior CVD (%)
		No	Yes	No	Yes	No	Yes	No	Yes	No	Yes
PDR	10			4.8	33.4	6.8	0.0	6.8	NA*	6.8	6.3
	15			5.2	24.8	6.6	25.4	6.6	62.0	6.6	13.0
	20			5.7	17.5	6.9	13.5	7.0	13.4	6.7	11.6
	25			8.2	21.4	10.2	16.2	10.2	37.6	11.0	5.9
CSME	10	5.1	15.5			5.6	0.0	5.5	NA*	5.4	11.7
	15	7.8	15.6			8.1	24.5	8.2	34.6	8.2	12.0
	20	9.1	17.9			9.4	29.1	9.8	15.4	9.5	14.5
	25	7.0	24.6			9.0	8.3	8.7	41.1	8.8	10.8
Reduced eGFR	10	1.7	6.0	1.4	6.9			1.9	NA*	1.8	10.3
	15	1.9	7.9	1.9	7.5			2.6	17.1	2.3	12.5
	20	4.1	8.4	3.9	8.6			4.5	38.2	4.6	8.9
	25	3.5	9.7	3.9	7.4			4.8	9.9	4.6	7.0
Amputation	10	NA*	NA*	NA*	NA*	NA*	NA*			NA*	NA*
	15	0.7	1.6	0.5	2.5	0.8	3.3			0.7	3.9
	20	0.5	2.0	0.3	2.5	0.5	6.5			0.6	3.2
	25	0.8	2.5	0.7	2.5	1.0	3.0			1.0	2.9
CVD	10	2.5	4.6	2.2	6.1	2.7	0.3	2.7	NA*
	15	3.5	6.7	3.8	4.6	3.9	7.6	3.8	25.0
	20	3.5	4.3	3.0	6.0	3.4	8.3	3.5	17.0
	25	5.2	10.4	5.6	8.6	6.0	12.2	6.3	21.2
Mortality	10	0.8	1.0	0.7	2.1	0.9	0.1	0.7	NA*	0.9	0.0
	15	1.9	2.8	1.8	3.0	1.4	27.5	1.9	0.1	1.5	14.8
	20	2.4	4.7	2.3	4.6	2.3	13.8	2.7	12.7	2.7	4.3
	25	3.7	5.1	3.7	4.7	3.7	7.7	3.4	29.4	3.2	11.7

NA, not applicable.

^†For example, an individual free of PDR at 10 years from randomization has a 4.8% chance of developing PDR in the next 5 years if they did not have CSME by year 10, compared with a 33.4% chance if they had CSME by year 10. Likewise, an individual free of CVD at 25 years from randomization has a 3.2% chance of death in the next 5 years if they did not have CVD by year 25, compared with an 11.7% chance if they had CVD by year 10.

^*There were no amputations prior to year 10; therefore, these probabilities are not estimable.