Table 2.
Association of urine LRG1 with risk of progression to ESKD
| Urine LRG1 | Model | |||
|---|---|---|---|---|
| Unadjusted | Multivariable | |||
| HR (95% CI) | P | HR (95% CI) | P | |
| Continuous | ||||
| 1 SD increment | 3.33 (2.69–4.11) | <0.001 | 1.53 (1.19–1.98) | 0.001 |
| Categorical, tertile | ||||
| 1 | Reference | Reference | ||
| 2 | 1.81 (0.98–3.37) | 0.06 | 1.18 (0.63–2.21) | 0.60 |
| 3 | 6.71 (3.94–11.42) | <0.001 | 1.91 (1.04–3.50) | 0.04 |
Cox PH regression model: time to ESKD as outcome; urine LRG1 was normalized to urine creatinine level and modeled as a continuous variable (1 SD log-transformed LRG1) and categorical variable (tertiles), respectively. Multivariable model adjusted for age, sex, ethnicity (Chinese as reference), smoking (active vs. others), CVD history (yes vs. no), BMI, diabetes duration, HbA1c, systolic blood pressure, diastolic blood pressure, baseline eGFR, and urine ACR (log transformed).