Fig. 2.

Demographic model used in simulations for MaLAdapt. We simulated an ancestral human population that diverged into an archaic human population and an ancestral African population. The latter population subsequently split into a Eurasian population and experienced two bottleneck events, representing Out-of-Africa migrations and a European–Asian split, followed by an exponential growth. Sometime between the two bottleneck events, the Eurasian population experienced a single pulse of archaic introgression at a varying time and amount, which introduced a mutation that later became beneficial in the Eurasian population. See supplementary Table S2, Supplementary Material online for the full range of simulation parameters.