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. 2023 Jan 11;40(1):msad010. doi: 10.1093/molbev/msad010

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© The Author(s) 2023. Published by Oxford University Press on behalf of Society for Molecular Biology and Evolution.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Fig. 3. — de novo-resistant mutants selected at subMICs of antibiotics have resistance levels that are above the clinical break-points. Resistance levels of mutants selected at subMICs of 1/4th, 1/200^th, and 1/2000th MIC_susceptible are plotted for (A) fosfomycin, those selected at subMICs 1/4th and 1/200th MIC_susceptible are plotted for (B) tetracycline, (C) nitrofurantoin, and those selected at subMICs of 1/4th and 1/10th MIC_susceptible are plotted for (D) ciprofloxacin. The absolute antibiotic concentrations used for selection are shown as dotted lines, while the clinical breakpoints are shown as solid lines. For fosfomycin, data points shown in the gray bar represent MIC values that are greater than the maximum that could be measured using an E-test, that is, the MIC for these strains is >1024 mg/L.