Table 1.

Glycosphingolipids are substantially increased in sensitized females exposed to ozone

		Male			Female
Cluster name	Class size	q value	Increased	Decreased	q value	Increased	Decreased
OxCer	4	1.1E−03	0	3	0.12	1	0
OxGlcCer	5	1	0	0	4.8E−05	4	0
OxSM	3	0.27	0	1	0.099	0	1
Saturated SM	6	2.8E−04	0	3	0.096	0	0
Unsaturated Cer	17	0.082	2	2	1.9E−03	1	3
Unsaturated GlcCer	12	1.5E−03	6	0	3.0E−14	11	0
Unsaturated SM	25	2.6E−11	0	18	1.6E−06	0	10

List of sphingolipid classes comparing the abundance in airways from sensitized, ozone-exposed males and females relative to control mice using chemical similarity enrichment analysis (ChemRICH). The number of individual metabolites contained within a group is indicated by class size. Sphingolipids that are increased or decreased between groups correspond to individual species with a fold-increase or decrease greater than 2. q values for each cluster were calculated using a Kolmogorov-Smirnov test followed by Benjamini-Hochberg adjustment for false-discovery rate (FDR), and q < 0.05 was used as the threshold for statistical significance. The full list of metabolite classes analyzed by ChemRICH included in Supplementary Table 5.