(A, B) Quantification of (A) Ca2+ transient amplitude of paced and caffeine-induced 10 nM Iso-stimulated WT and MHC-Plin5 cardiomyocytes (nheart = 4 [WT], 3 [MHC-Plin5]; ncell = 24–27 [WT], 17–18 [MHC-Plin5]) and (B) Ca2+ decay rates during systole in paced 10 nM Iso-stimulated cardiomyocytes (nheart = 4 [WT], 3 [MHC-Plin5]; ncell = 24 [WT], 17 [MHC-Plin5]). (A, B) Values are the mean ± SEM; P-values are calculated by one-way ANOVA followed by Sidak’s multiple comparisons post hoc tests for (A) and a t test for (B).