Table 2.
Cardiac Plin5 overexpression does not lead to early myocardial failure in 27-wk-old mice.
| Parameters | WT (n = 10) | MHC-Plin5 (n = 9) | P-value |
|---|---|---|---|
| Body weight (g) | 41.1 ± 1.3 | 38.9 ± 1.5 | 0.288 |
| LV mass (mg) | 130.0 ± 5.2 | 147.0 ± 10.8 | 0.162 |
| RWT | 0.43 ± 0.02 | 0.49 ± 0.03 | 0.110 |
| LVAWD(d) (mm) | 0.94 ± 0.03 | 1.04 ± 0.04 | 0.050 |
| LVPWD(d) (mm) | 0.77 ± 0.02 | 0.87 ± 0.07 | 0.194 |
| LVED(d) (mm) | 4.03 ± 0.11 | 3.95 ± 0.11 | 0.579 |
| LVVol(d) (µl) | 72.1 ± 4.7 | 68.4 ± 4.7 | 0.590 |
| Ejection fraction (%) | 71.7 ± 2.6 | 80.6 ± 2.8 | 0.033 |
| Stroke volume (µl) | 37.7 ± 1.9 | 46.1 ± 2.6 | 0.018 |
| Heart rate (bpm) | 414 ± 23 | 367 ± 28 | 0.209 |
| Cardiac output (ml/min) | 16.8 ± 1.7 | 16.9 ± 1.6 | 0.962 |
Cardiac morphological and functional parameters assessed by echocardiography in 27-wk-old WT and MHC-Plin5 mice. RWT, relative wall thickness; LVAWD(d), LV anterior wall dimension in diastole; LVPWD(d), LV posterior wall dimensions in diastole; LVED(d), LV end-diastolic dimension; and LVVol(d), LV end-diastolic volume LVED(d). Results are expressed as the mean ± SEM; P-values are calculated by a t test; significant P-values (<0.05) are shown in bold.