Table 3.
Cardiac Plin5 overexpression does not lead to diastolic dysfunction in 27-wk-old mice.
| Parameters | WT (n = 10) | MHC-Plin5 (n = 7) | P-value |
|---|---|---|---|
| Body weight (g) | 37.3 ± 1.2 | 38.8 ± 2.3 | 0.548 |
| Heart rate (bpm) | 465 ± 23 | 405 ± 20 | 0.077 |
| DT (ms) | 26.3 ± 1.6 | 31.1 ± 3.2 | 0.167 |
| E (mm/s) | 662.4 ± 18.4 | 605.9 ± 27.7 | 0.097 |
| A (mm/s) | 467.5 ± 33.1 | 487.1 ± 22.5 | 0.663 |
| E/A ratio | 1.46 ± 0.08 | 1.25 ± 0.05 | 0.060 |
| E/E’ ratio | 42.23 ± 2.99 | 46.50 ± 3.42 | 0.366 |
| MPI | 0.738 ± 0.027 | 0.721 ± 0.035 | 0.707 |
Echocardiographic parameters of left ventricular diastolic function in 27-wk-old WT and MHC-Plin5 mice. DT, deceleration time; and MPI, myocardial performance index. Results are expressed as the mean ± SEM; P-values are calculated by a t test.