Fig. 1.

c-MYC is responsible for the crosstalk between breast cancer cells and tumor microenvironment. Within the tumor microenvironment, c-MYC can be regulated by several signaling proteins, such as STAT3, MAPK, β-catenin and mTOR. In addition, c-MYC contributes to the regulation of angiogenesis, the function of CAF and EMT. Moreover, c-MYC is able to modulate TAM, NK cell, T and B cell, as well as the expression of PD-L1 and CD47, thus leading to the immune evasion and immunosuppression. Besides, the tumor microenvironment can affect c-MYC expression in turn by various cytokines, the hypoxia microenvironment and the factors released from CAF