Fig. 7.

Effect of macrophage depletion on UDCA-mediated alleviation of intestinal inflammation in DSS-treated mice (n = 8). A Schematic outline of the experimental design. B Daily body weight changes. C Disease activity index score. D Representative images of the colon. E Colon length. F Histology score. G Representative H&E staining (×50 magnification) of the colon sections. The mRNA expression levels of two inflammatory cytokines, IL-1β (H) and TNF-α (I), in the colon. Data are presented as means ± SEM. *P < 0.05, **P < 0.01, *** P < 0.001; ^#P < 0.05, relative to the DSS+UDCA group; ^θP < 0.05, relative to their respective clodronate treated groups