Table 4.
Outcomes of the included trials
| Statistician blinded prior to the final analysis | |||
|---|---|---|---|
| No (N=83) | Yes (N=69) | Unclear (N=27) | |
| Statistically significant finding reported for primary outcome, n/N (%) | 23/83 (28%) | 19/69 (28%) | 8/27 (30%) |
| Sample size planned | |||
| Mean [SD] | 1686.1 [5326.6] | 1178.6 [2110.7] | 1151.7 [1313.9] |
| Median [25th, 75th centile] | 540 [240, 900] | 480 [312, 1200] | 544 [308, 1180] |
| Sample size achieved | |||
| Mean [SD] | 1647 [5433.7] | 1304.7 [2888.8] | 1116 [1424.4] |
| Median [25th, 75th centile] | 540 [269, 1010] | 475 [300, 1023] | 487 [247, 1211] |
| Target sample size achieved, n/N (%) | 56/83 (67%) | 52/69 (75%) | 15/27 (56%) |
| Percentage of target sample size achieved | |||
| Mean [SD] | 98.2 [25.7] | 100.7 [24.8] | 99 [60.1] |
| Median [25th, 75th centile] | 100.6 [97.4, 105.8] | 101 [100, 107.4] | 100 [83.2, 102.6] |
| Percentage of primary outcome data missing | |||
| Mean [SD] | 9.3 [11.4] | 13.7 [10.4] | 14.8 [15.6] |
| Median [25th, 75th centile] | 4 [1, 16] | 11.5 [6, 20] | 9 [3, 23] |
| Unclear, n | 1 | 3 | 0 |
| Missing data imputed for primary outcome, n/N (%) | 16/82 (20%) | 20/65 (31%) | 10/26 (38%) |
| Unclear, n | 1 | 4 | 1 |
Unless otherwise specified the table displays frequencies and column percentages
SD standard deviation