Table 2:

Hierarchical regression analysis of pain domains (pain impact, pain severity, and pain disability) predicting physical function and brain-PAD

	Pain Impact		Pain Severity		Pain Disability
Dependent variables	Standardized b	p	Standardized b	p	Standardized b	p
Physical Function
Balance	−0.153	0.031	−0.132	0.089	−0.087	0.233
Sit to Stand	−0.257	<0.001	−0.280	<0.001	−0.112	0.109
Walk	−0.162	0.015	−0.161	0.034	−0.158	0.028
Total SPPB score	−0.310	<0.001	−0.315	<0.001	−0.160	0.024
Epigenetic Clock
DNAmGrimAge	0.146	<0.001	0.153	<0.001	0.170	<0.001

^*note: SPPB – Short physical performance battery