Table 4.
Summary of functional MRI studies.
| Author (year) | Sample age (n) | Cognitive domain | Effect of Age on BOLD Activity | ||
|---|---|---|---|---|---|
| Frontal | MTL | Posterior | |||
| Task-related fMRI | |||||
| Beeri et al. (2011) | 70–90+ (29) | Recognition memory | o | − | − |
| Wang et al. (2009) | 64–96 (34) | Recognition memory | o | o | − |
| Rosano et al. (2005a) | 12–82+ (28) | Executive control | − | − | |
| Rosano et al. (2005b) | M=80–82 (16) | Executive control | +CI > CN | +CI > CN | |
| Kennedy et al. (2015) | 20–89 (316) | Semantic judgments | − | − | − |
| Resting state fMRI | Default mode | Frontoparietal | Motor | ||
| Prawiroharjo et al. (2020) | 65–80+ (44) | Recall memory | + | + | |
| Jiang et al. (2020) | 76–103 (104) | Visuospatial task | − | + | + |
| Li et al. (2020) | M=82 (34) | Δ General cognition | + | + | |
Notes. For each functional modality and brain region (task-related) or network (resting state), symbols indicate positive (+), negative (−), or non-significant (o) associations between age and BOLD activity. All studies are sorted by the cognitive domain examined. Superscripts indicate that the effect was seen for cognitively impaired (CI) versus normal (CN) subgroups. Δ = longitudinal change.