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. 2023 Jan 17;13:1060736. doi: 10.3389/fgene.2022.1060736

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Copyright © 2023 Arer and Kar.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Representation of CTXM-64-sulbactam complex. (A) Sulbactam-CTX-M-64 pocket interactions. The sulbactam-CTX-M-64 crystal structure shows the residues in the region of the binding pocket as cyan sticks, with atoms colored according to their types. Gold represents acrylic acid (AKR) and trans-enamine intermediate (TSL), with each kind of atom colored differently. (B) Sulbactam derivatives are highlighted in red on the CTX-M-64 pocket’s 2FoFc map, which has been contoured at 3.0 σ around them. Cyan sticks represent residues around the binding pocket, whereas gold sticks represent AKR and TSL. (Adapted from Cheng et al., 2019).