FIG 1.

Characterization of LCMV-specific memory CD8 T cell subsets after acute infection. (a and b) Frequency (a) and absolute number (b) of tetramer⁺ CD8 T cells in the spleen after LCMV Armstrong infection of B6 mice (2 × 10⁵ PFU, intraperitoneal [i.p.]). D^bGP33⁺, D^bGP276⁺, and D^bNP396⁺ responses are shown. (c) Representative flow plots showing the frequency of GP33⁺ CD8 T cells and the expression of KLRG1 and IL-7Rα within them from 8 days to 1 year postinfection. (d to f) Summary of the frequency and absolute number of the indicated subpopulations within GP33⁺, GP276⁺ or NP396⁺ CD8 T cells. IL-7Rα⁺KLRG1⁻ memory precursors (MPs, blue), IL-7Rα⁺KLRG1⁺ cells (KLRG1⁺ MPs, green), IL-7Rα-KLRG1⁺ terminal effectors (TEs, orange), IL-7Rα-KLRG1⁻ double negative cells (DNs, red). Shown are the mean and SEM; n = 5 to 12 mice per time point.