FIG 6.

PTCs had distinct transcriptomic features from NCs during ATI. PTCs had lower levels of inflammation, cell death, and HIV-dependent factors during ATI. (A) Normalized Enrichment Scores (NES) for the curated pathways, highlighting the enrichment of inflammatory, cell death, and HIV-dependent pathways in NCs, compared to PTCs, during pre-ATI, early ATI, and late ATI. (B) Gene set enrichment in selected pathways at different time points. NES, normalized enrichment score. (C) Longitudinal NES for different pathways in PTCs and NCs. The NES were derived from a within-group comparison, namely, the transcriptome obtained during ATI versus that obtained in pre-ATI in PTCs and in NCs, respectively.