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. 2023 Jan 12;97(1):e01673-22. doi: 10.1128/jvi.01673-22

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Copyright © 2023 Wrapp et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license.

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FIG 2 — The 2P mutations do not alter the antigenic landscape of CH848 10.17DT DS-SOSIP. (A and B) ELISA binding curves for Env-directed monoclonal antibodies against CH848 10.17DT DS-SOSIP and CH848 10.17DT DS-SOSIP-2P are shown. CH848 10.17DT DS-SOSIP is shown in black, and CH848 10.17DT DS-SOSIP-2P is shown in purple. Data points represent the average of three replicates, and the standard deviations are plotted as error bars. The y axes show absorbance measured at 450 nm. Neutralizing antibody curves (A) and nonneutralizing antibody curves (B) are shown. DH270 UCA, DH270.6, PGT125, PGT128, and 2G12 target the V3 glycan epitope. PGT151 recognizes cleaved trimers at the gp120/gp41 interface. N6 targets the CD4-binding site (CD4bs). F105 and 17b bind to open conformations of the CD4bs and coreceptor-binding site, respectively. A32 binds to the C1C2 domain of gp120. F39F and 19b both recognize a flexible conformation of the V3 loop.