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Applying 2P mutations to evolutionarily diverse Env constructs. Size-exclusion chromatograms are shown for each construct after PGT145 affinity chromatography. Curves for the 2P-stabilized construct are colored, and the curves for the corresponding non-2P-stabilized constructs (“WT”) are overlaid in black. Chromatograms were generated using a Superose 6 Increase column. Full details about these Env constructs can be found in Table S3 in the supplemental material.
