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. 2023 Feb 1;133(3):e158705. doi: 10.1172/JCI158705

Figure 1. FAM117B promotes the growth and chemoresistance of gastric cancer cells.

Figure 1

(A and B) FAM117B protein levels in HGC-27 and AGS cells transfected with FAM117B shRNAs (#1 and #2) or overexpression plasmids (n = 3 independent experiments). (C and D) Cell growth ability of HGC-27 and AGS cells with FAM117B knockdown or overexpression (n = 3 independent experiments). (E) Colony formation ability of HGC-27 and AGS cells with FAM117B knockdown or overexpression (n = 3 independent experiments). (F and G) Therapeutic efficacy of 5-FU and oxaliplatin on HGC-27 and AGS cells with FAM117B knockdown or overexpression (n = 3 independent experiments). Data are shown as mean ± SD. ***P < 0.001, significant difference vs. shControl or Vector group. Statistical significance was calculated using 2-tailed unpaired Student’s t test (2 groups) or 1-way ANOVA followed by Tukey’s test (more than 2 groups).