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. 2023 Feb 1;133(3):e158705. doi: 10.1172/JCI158705

Figure 2. FAM117B activates KEAP1/NRF2 signaling in gastric cancer cells.

Figure 2

(A and B) Protein levels of NRF2 and KEAP1 in HGC-27 and AGS cells with FAM117B knockdown or overexpression (n = 3 independent experiments). (C and D) Protein levels of NRF2 in cytoplasm and nucleus of HGC-27 and AGS cells with FAM117B knockdown or overexpression (n = 3 independent experiments). (E) mRNA levels of NRF2 target genes in HGC-27 and AGS cells with FAM117B knockdown or overexpression (n = 3 independent experiments). The colors of the heatmap represent values of –ΔΔCt. Data are shown as mean ± SD. ***P < 0.001, significant difference vs. shControl or Vector group. Statistical significance was calculated using 2-tailed unpaired Student’s t test (2 groups) or 1-way ANOVA followed by Tukey’s test (more than 2 groups).