. Author manuscript; available in PMC: 2023 Jan 31.

Published in final edited form as: Epilepsia. 2022 Aug 9;63(10):2445–2460. doi: 10.1111/epi.17329

Table 4.

Typical stimulation settings for VNS, DBS, and RNS

		Current, voltage, or charge density			Pulse width	Frequency	Duty cycle %, ON/OFF (min)
		Initial	Increment	Target			Initial	Target
VNS	Normal mode	0.125 - 0.25 mA	0.125 - 0.25 mA	1.5-2 mA	250 μs	20-30 Hz	10%, 0.5 ON / 5 OFF	16-58%
	Autostim	0.25 - 0.375 mA	0.125 - 0.25 mA	1.5-2 mA	250 μs	20-30 Hz	ON 1	ON 1
	Magnet mode	0.5 mA	0.25 mA	2 mA	500 μs	20-30 Hz	ON 1	ON 1
DBS (ANT)	SANTE protocol	2-3 mA/V per cathode	1-2 mA/V	5-6 mA/V	90 μs	145 Hz	17%, 1 ON / 5 OFF
RNS	Initial	0.5 μC/cm²	0.5 μC/cm²	2-6 μC/cm²	160 μs	200 Hz