. 2023 Jan 27;15:29–40. doi: 10.2147/JEP.S398487

Table 6.

Anti-Inflammatory Effect of the Solvent Fractions of V. auriculifera on Carrageenan-Induced Paw Edema in Rats

Change in Paw Volume (mL) (Mean ±S.E.M) (Percent Inhibition %)
Group	Basal Volume	1 Hour	2 Hours	3 Hours	4 Hours
TW	0.63 ± 0.01	1.15 ± 0.01	1.23 ± 0.01	1.19 ± 0.01	1.18 ± 0.00
AQF100	0.64 ± 0.01	1.05 ± 0.01^a (8.6)	0.88 ± 0.01^a (28.45)	0.86 ± 0.01^a (27.73)	0.78 ± 0.02^a (33.89)
AQF200	0.66 ± 0.01	1.03 ± 0.009^a (10.43)	0.87 ± 0.01^a (29.26)	0.86 ± 0.03^a (27.73)	0.70 ± 0.02^a (40.67)
AQF400	0.65 ± 0.01	0.95 ± 0.01^abc (17.39)	0.79 ± 0.007^abc (35.77)	0.75 ± 0.01^abc (36.97)	0.62 ± 0.02^ab (47.45)
EAF100	0.63 ± 0.01	1.07 ± 0.01^a (6.9)	0.91 ± 0.01^a (26.01)	0.87 ± 0.01^a (26.89)	0.81 ± 0.02^a (31.85)
EAF200	0.65 ± 0.01	1.04 ± 0.009^a (9.5)	0.90 ± 0.01^a (26.82)	0.83 ± 0.006^a (30.25)	0.72 ± 0.02^a (38.98)
EAF400	0.63 ± 0.01	0.96 ± 0.009^aef (16.52)	0.81 ± 0.01^aef (34.14)	0.76 ± 0.02^aef (36.13)	0.64 ± 0.02^ae (45.76)
MEF100	0.65 ± 0.01	1.04 ± 0.01^a (9.56)	0.88 ± 0.02^a (28.45)	0.81 ± 0.01^a (31.93)	0.73 ± 0.01^a (38.13)
MEF200	0.64 ± 0.007	1.00 ± 0.01^a (13.04)	0.85 ± 0.01^a (30.89)	0.76 ± 0.01^a (36.13)	0.66 ± 0.01^a (44.06)
MEF400	0.65 ± 0.01	0.91 ± 0.009^ahi (20.86)	0.75 ± 0.01^ahi (38.21)	0.70 ± 0.00^ahi (41.17)	0.59 ± 0.01^ah (50)
IND	0.65 ± 0.01	0.78 ± 0.009^adgj (32.17)	0.74 ± 0.02^acfi (39.83)	0.68 ± 0.009^acfi (42.85)	0.56 ± 0.01^abeh (52.54)

Notes: ^aAgainst negative control, ^bagainst AQF 100mg/kg, ^cagainst AQF 200 mg/kg, ^dagainst AQF 400 mg/kg, ^eagainst EAF 100 mg/kg, ^fagainst EAF 200 mg/kg, ^gagainst EAF 400 mg/kg, ^hagainst MEF 100 mg/kg, ⁱagainst MEF 200 mg/kg, ^jagainst MEF 400 mg/kg; TW, 2% Tween 80 10mL/kg; IND, Indomethacin 10mg/kg; p < 0.05.

Abbreviations: AQF, aqueous fraction; EAF, ethyl acetate fraction; MEF, methanol fraction.