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. Author manuscript; available in PMC: 2023 Jan 31.
Published in final edited form as: Arch Biochem Biophys. 2022 Nov 25;733:109472. doi: 10.1016/j.abb.2022.109472

Fig. 1.

Fig. 1.

The enzymatic reaction of h12-LOX with AA, producing 12S-HpETE is shown (Insert) and a h12-LOX structural model [19] with Y649 highlighted in pink, L407 (a critical active site residue) highlighted in blue and the active site iron in yellow. The proposed solution-state dimer is shown on the left, with one monomer shown as a dimmed grey space-filling model and the other monomer shown as a grey ribbon model. The other two images are of only the cartoon monomer, for clarity of presentation.