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. 2023 Jan 10;73(727):e75–e87. doi: 10.3399/BJGP.2022.0371

Table 2.

Age (years) at which modelled 9-month cancer risk (%) exceeded 2%, 3%, and 6% in patients with fatigue without co-occurring alarm symptoms/anaemia, by presence of each co-occurring vague symptoma

Characteristic Males, age in years Females, age in years

Risk >2% Risk >3% Risk >6% Risk >2% Risk >3% Risk >6%
Patients with fatigue, without alarm symptoms or anaemia
With vague symptoms 63 70 75
Without vague symptoms 67 78

Pairwise combinations of fatigue with each vague symptom
Abdominal bloating 65 72 64 80
Abdominal pain 60 65 90 64 79
Back pain 67 80
Chest pain 64 70 77
Constipation 62 67 68
Cough 66 75
Diarrhoea 63 69
Other upper GI symptoms 61 67 68
Dyspnoea 65 72 71
Headache 66 74
Lower RTI 65 72
Other musculoskeletal pain 67 79
Testicular pain 64 71
Thromboembolic disease 71 95 99
Upper RTI 66 75
Urinary tract infections 66 77
Weight loss 55 59 67 59 65
a

Urinary tract infections also include cystitis, dysuria, urgency, painful urination, urine smell. Other upper GI symptom includes dyspepsia, nausea, vomiting, haematemesis, loss of appetite. GI = gastrointestinal. RTI = respiratory tract infections.