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. 2023 Jan 31;20(1):e1004167. doi: 10.1371/journal.pmed.1004167

Table 2. Association of ZIP code characteristics with the percent of residents aged 5 years and older that are vaccinated for COVID-19 and/or have had a COVID-19 booster shot.

a) Percent vaccinated
Bivariate Multivariable
OLS regression models (1) (2) (3) (4)
beta (95% CI) p-value beta (95% CI) p-value beta (95% CI) p-value beta (95% CI) p-value
Median household income ($10k increase) 4.5*** (3.8,5.2) <0.001 4.8*** (3.3,6.3) <0.001 1.5 (−0.1,3.1) 0.060 1.5 (−0.1,3.1) 0.059
Percent college graduates (10% point increase) 2.9*** (2.2,3.6) <0.001 2.3*** (1.1,3.6) <0.001 5.1*** (3.9,6.3) <0.001 5.1*** (3.9,6.3) <0.001
Percent Black, Latino, Indigenous (10% point increase) −0.8** (−1.3,−0.3) 0.002 1.4*** (0.8,2.0) <0.001 1.8*** (1.1,2.6) <0.001 1.9*** (1.0,2.8) <0.001
Percent essential worker (10% point increase) −5.5*** (−7.3,−3.8) <0.001 4.5*** (2.1,6.8) <0.001 4.8*** (2.6,7.1) <0.001 4.8*** (2.6,7.1) <0.001
VEI community (0,1) −4.0** (−6.4,−1.6) 0.001 −0.3 (−3.6,3.0) 0.850
Adjusted for age distribution No No Yes Yes
R2 NA 0.38 0.47 0.47
b) Percent with a booster shot (dependent variable)
Bivariate Multivariable
OLS regression models (1) (2) (3) (4)
beta (95% CI) p-value beta (95% CI) p-value beta (95% CI) p-value beta (95% CI) p-value
Median household income ($10k increase) 6.8*** (6.2,7.4) <0.001 3.7*** (2.2,5.2) <0.001 0.6 (−0.8,2.0) 0.392 0.6 (−0.7,1.9) 0.351
Percent college graduates (10% point increase) 5.1*** (4.5,5.6) <0.001 2.8*** (1.6,4.1) <0.001 5.5*** (4.5,6.4) <0.001 5.4*** (4.5,6.4) <0.001
Percent Black, Latino, Indigenous (10% point increase) −2.6*** (−3.0,−2.2) <0.001 −0.1 (−0.4,0.3) 0.687 0.8*** (0.4,1.2) <0.001 1.0*** (0.5,1.5) <0.001
Percent essential worker (10% point increase) −11.0*** (−12.4,−9.6) <0.001 0.2 (−1.7,2.2) 0.801 0.3 (−1.3,1.9) 0.714 0.4 (−1.2,1.9) 0.630
VEI community (0,1) −11.1*** (−13.4,−8.8) <0.001 −2.1 (−4.4,0.2) 0.079
Adjusted for age distribution No No Yes Yes
R2 NA 0.67 0.76 0.76

Note: N = 418 ZIP codes. In column (1), each cell shows the result of a separate bivariate OLS regression model. In columns (2)–(4), each column shows the results of multivariable (adjusted) OLS regression models. Coefficients are scaled so that they can be interpreted as the percentage point change in primary series (or booster) coverage associated with a 10% (or $10K) increase in the continuous covariates. 95% CIs based on heteroskedasticity-robust standard errors are shown in parentheses. We adjusted for age by including variables denoting the percentage of ZIP code residents in the following age groups: 5–19, 20–39, 40–64, and 65+ years.

*p < 0.05,

**p < 0.01,

***p < 0.001.

CI, confidence interval; OLS, ordinary least squares; VEI, Vaccine Equity Initiative.