Table 4 .
Summary of findings table of RCME versus LC
| RCME compared with LC for colonic cancer | |||||
|---|---|---|---|---|---|
| Patient or population: colonic cancer Setting: Intervention: RCME; Comparison: LC | |||||
| Outcomes | No. of participants (studies) |
Certainty of the evidence (GRADE) |
Relative effect (95% CI) |
Anticipated absolute effects | |
| Risk with LC | Risk difference with RCME | ||||
| Conversion | 677 (7 observational studies) |
⨁⨁⨁◯ Moderate |
OR 0.17 (0.04 to 0.74) |
47 per 1,000 |
38 fewer per 1,000 (45 fewer to 12 fewer) |
| Operative time | 677 (7 observational studies) |
⨁◯◯◯ Very lowa,b |
– | – | MD 36.32 higher (24.3 lower to 96.93 higher) |
| Morbidity | 677 (7 observational studies) |
⨁⨁◯◯ Low |
OR 1.03 (0.70 to 1.53) |
199 per 1,000 |
5 more per 1,000 (51 fewer to 76 more) |
| Anastomosis leak | 677 (7 observational studies) |
⨁⨁⨁◯ Moderate |
OR 0.83 (0.18 to 3.72) |
15 per 1,000 |
2 fewer per 1,000 (12 fewer to 38 more) |
| Hospital stay | 677 (7 observational studies) |
⨁⨁◯◯ Lowb |
– | – | MD 0.94 lower (2.03 lower to 0.15 higher) |
| Bleeding | 677 (7 observational studies) |
⨁⨁◯◯ Low |
OR 1.90 (0.64 to 5.58) |
17 per 1,000 |
15 more per 1,000 (6 fewer to 72 more) |
| Wound infection | 581 (6 observational studies) |
⨁⨁◯◯ Lowb |
OR 0.82 (0.37 to 1.78) |
55 per 1,000 |
9 fewer
per 1,000 (34 fewer to 39 more) |
| DFS | 391 (3 observational studies) |
⨁◯◯◯ Very lowa,b |
OR 1.29 (0.71 to 2.35) |
844 per 1,000 |
31 more per 1,000 (51 fewer to 83 more) |
| DFS | All studies 3 | 139/160 | 195/231 1.29 [0.71, 2.35] | 0 (0%) | 0.41 |
RCME = robotic complete mesocolon excision; LC = laparoscopic colectomy; CI = confidence interval; MD = mean difference; OR = odds ratio; DFS = disease-free survival
The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI).
GRADE Working Group grades of evidence:
High certainty: we are very confident that the true effect lies close to that of the estimate of the effect.
Moderate certainty: we are moderately confident in the effect estimate; the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different.
Low certainty: our confidence in the effect estimate is limited; the true effect may be substantially different from the effect estimate.
Very low certainty: we have very little confidence in the effect estimate; the true effect is likely to be substantially different from the estimate of effect.
aI2 superior to 50% with a p-value less than 0.0001 suggesting substantial heterogeneity.
bSmall sample size suggesting issues with imprecision.