TABLE 4.
Factors Associated with Refractory CIP
| Univariate Analysis | Multivariable Analysis | |||
|---|---|---|---|---|
| Variable | OR (95% CI) | P | OR (95% CI) | P |
| Best response of ICI | 0.558 | - | - | |
| PR vs. PD | 0.357 (0.074- 2.740) | 0.322 | - | - |
| SD vs. PD | 0.333 (0.041- 2.699) | 0.303 | - | - |
| Time to CIP (<6w vs. ≥6w) | 4.500 (1.297- 15.611) | 0.018 | 3.812 (0.193- 75.405) | 0.380 |
| Symptoms | 0.213 | - | - | |
| Shortness of breath vs. cough | 7.917 (1.473- 42.538) | 0.016 | 7.506 (0.340- 165.578) | 0.202 |
| Shortness of breath vs. fever | 1.667 (0.330- 8.423) | 0.537 | - | - |
| LDH at baseline (≥255 vs. <255) | 3.733 (0.917- 15.207) | 0.066 | 0.926 (0.090- 9.512) | 0.948 |
| LDH at CIP (≥320 vs. <320) | 11.333 (2.209- 58.147) | 0.004 | 8.889 (1.294- 61.058) | 0.026 |
| Changes of LDH from baseline to CIP development (≥66 vs. <66) | 12.083 (2.053- 71.114) | 0.006 | 5.160 (0.598- 44.514) | 0.136 |
Statistically significant P and corresponding odds ratio values are in bold.
CI indicates confidence interval; CIP, checkpoint inhibitor-related pneumonitis; ICI, immune checkpoint inhibitor; LDH, lactate dehydrogenase; OR, odds ratio; PD, progression of disease; PR, partial response; SD, stable disease.