Table 1. Prevalence of HPV types in cases with cervical intraepithelial neoplasia grade 1, 2, and 3.
| HPV types | All CIN (n=1,480) | CIN 1 (n=740) | CIN 2 (n=396) | CIN 3 (n=344) | CIN2/3 (n=740) |
P for CIN2/3
vs. CIN1 |
|||||||||
| n |
Prevalence
(95% CI) |
n |
Prevalence
(95% CI) |
n |
Prevalence
(95% CI) |
n |
Prevalence
(95% CI) |
n |
Prevalence
(95% CI) |
||||||
| Abbreviation: CIN=cervical intraepithelial neoplasia; HPV=human papillomavirus; CI=confidence interval; ASC–US=atypical squamous cells of undetermined significance; NA=not available. | |||||||||||||||
| All HPV+ | 1,259 | 85.1 (83.2–86.9) | 577 | 78.0 (74.8–80.9) | 358 | 90.4 (87.1–93.1) | 324 | 94.2 (91.2–96.4) | 682 | 92.2 (90.0–94.0) | <0.001 | ||||
| Normal | 106 | 7.2 (5.9–8.6) | 70 | 9.5 (7.5–11.6) | 24 | 6.1 (3.9–8.9) | 12 | 3.5 (1.6–5.4) | 36 | 4.9 (3.4–6.7) | <0.001 | ||||
| ASC–US or worse | 1,120 | 75.7 (73.5–77.9) | 489 | 66.1 (62.5–69.5) | 328 | 82.8 (78.8–86.4) | 303 | 88.1 (84.2–91.3) | 631 | 85.3 (82.5–87.8) | <0.001 | ||||
| HPV-16 | 496 | 33.5 (31.1–36.0) | 137 | 18.5 (15.8–21.5) | 165 | 41.7 (36.8–46.7) | 194 | 56.4 (51.0–61.7) | 359 | 48.5 (44.9–52.2) | <0.001 | ||||
| Normal | 36 | 2.4 (1.7–3.4) | 17 | 2.3 (1.3–3.7) | 11 | 2.8 (1.4–4.9) | 8 | 2.3 (1.0–4.5) | 19 | 2.6 (1.6–4.0) | 0.745 | ||||
| ASC–US or worse | 452 | 30.5 (28.2–33.0) | 119 | 16.1 (13.5–18.9) | 152 | 38.4 (33.6–43.4) | 181 | 52.6 (47.2–58.0) | 333 | 45.0 (41.4–48.7) | <0.001 | ||||
| HPV-18 | 92 | 6.2 (5.0–7.6) | 57 | 7.7 (5.9–9.9) | 22 | 5.7 (3.5–8.3) | 13 | 3.8 (2.0–6.4) | 35 | 4.7 (3.3–6.5) | 0.018 | ||||
| Normal | 15 | 1.0 (0.5–1.5) | 11 | 1.5 (0.7–2.6) | 4 | 1.0 (0.3–2.6) | NA | NA | 4 | 0.5 (0.2–1.4) | 0.069 | ||||
| ASC–US or worse | 71 | 4.8 (3.8–6.0) | 42 | 5.7 (4.1–7.6) | 17 | 4.3 (2.5–6.8) | 12 | 3.5 (1.8–6.0) | 29 | 3.9 (2.6–5.6) | 0.114 | ||||
| Other HPV types | 895 | 60.5 (57.9–63.0) | 476 | 64.3 (60.8–67.8) | 237 | 59.9 (54.8–64.7) | 182 | 52.9 (47.5–58.3) | 419 | 56.6 (53.0–60.2) | 0.002 | ||||
| Normal | 69 | 4.7 (3.7–5.9) | 50 | 6.8 (5.1–8.8) | 13 | 3.3 (1.8–5.6) | 6 | 1.7 (0.6–3.8) | 394 | 2.6 (1.6–4.0) | <0.001 | ||||
| ASC–US or worse | 804 | 54.3 (51.8–56.9) | 410 | 55.4 (51.7–59.0) | 221 | 55.8 (50.8–60.8) | 173 | 50.3 (44.9–55.7) | 19 | 53.2 (49.7–56.8) | 0.404 | ||||
| HPV-16/18 | 573 | 38.7 (36.2–41.3) | 188 | 25.4 (22.3–28.7) | 184 | 46.5 (41.5–51.5) | 201 | 58.4 (53.0–63.7) | 385 | 52.0 (48.4–55.7) | <0.001 | ||||
| Normal | 49 | 3.3 (2.5–4.4) | 26 | 3.5 (2.3–5.1) | 15 | 3.8 (2.1–6.2) | 8 | 2.3 (1.0–4.5) | 23 | 3.1 (2.0–4.6) | 0.663 | ||||
| ASC–US or worse | 510 | 34.5 (32.0–36.9) | 157 | 21.2 (18.3–24.3) | 166 | 41.9 (37.0–47.0) | 187 | 54.4 (48.9–59.7) | 353 | 47.7 (44.1–51.3) | <0.001 | ||||
| Other HPV types (no 16/18) | 686 | 46.4 (43.8–49.0) | 389 | 52.6 (48.9–56.2) | 174 | 43.9 (39.0–49.0) | 123 | 35.8 (30.7–41.1) | 297 | 40.1 (36.6–43.7) | <0.001 | ||||
| Normal | 57 | 3.9 (2.9–5.0) | 44 | 6.0 (4.2–7.7) | 9 | 2.3 (1.0–4.3) | 4 | 1.2 (0.1–2.3) | 13 | 1.8 (0.9–3.0) | <0.001 | ||||
| ASC–US or worse | 610 | 41.2 (38.7–43.8) | 332 | 44.9 (41.3–48.5) | 162 | 40.9 (36.0–45.9) | 116 | 33.7 (28.7–38.7) | 278 | 37.6 (34.1–41.2) | 0.004 | ||||
| HPV-18 related (no 16) | 77 | 5.2 (4.1–6.3) | 51 | 6.9 (5.2–9.0) | 19 | 4.8 (2.9–7.4) | 7 | 2.0 (0.8–4.2) | 26 | 3.5 (2.3–5.1) | 0.003 | ||||
| Normal | 13 | 0.9 (0.4–1.4) | 9 | 1.2 (0.6–2.3) | 4 | 1.0 (0.1–2.0) | NA | NA | 4 | 0.5 (0.2–1.4) | 0.164 | ||||
| ASC–US or worse | 58 | 3.9 (3.0–5.0) | 38 | 5.1 (3.7–7.0) | 14 | 3.5 (1.7–5.4) | 6 | 1.7 (0.4–3.1) | 20 | 2.7 (1.5–3.9) | 0.016 | ||||