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. 2022 Oct 17;19(2):151–158. doi: 10.1038/s41589-022-01142-z

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 7 — a, Processing scheme for classification and refinement of ClbP. Locally filtered map with dust hidden used for the final reconstruction for clarity. b, Superposition of the cryo-EM (tan) and crystal (gray) structures of dimeric ClbP. Both structures are nearly identical (RMSD of 0.830 Å over 904 residues), except for a ~5° bend of the TMDs towards the center of the dimer cavity in the cryo-EM structures. c, Superposition of the cryo-EM and crystal structures focusing on a single subunit. View related to b by a 90° rotation. d, The 3D reconstruction of dimeric ClbP revealed a branched density in the active site that likely corresponds to a copurified lipid. Density is contoured at 5.5σ and the catalytic triad residues are shown as sticks for reference.