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. 2022 Aug 10;44(2):308–320. doi: 10.1038/s41401-022-00941-3

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© The Author(s), under exclusive licence to Shanghai Institute of Materia Medica, Chinese Academy of Sciences and Chinese Pharmacological Society 2022, Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

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Fig. 8 — Roxadustat ameliorated NTG-induced migraine by activating HIF-1α, which is mainly mediated by reducing NF-κB/inflammation pathway to attenuate central sensitization markers, p-ERK1/2, and c-Fos. HIF-1α activators might be potential drugs for treatment of migraine.