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. 2022 Dec 6;149(1):159–171. doi: 10.1007/s00432-022-04500-5

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Survival analysis according to change of plasma GDF15 levels in patients with lung cancer treated with PD-1/PD-L1 inhibitors. A Progression-free survival (PFS). The median PFS in the decreased GDF15 levels group was 14.8 months (95% CI 10.4–19.2), significantly longer than 5.9 months (95% CI 2.8–9, P = 0.002). B Overall survival (OS). The median OS in the decreased GDF15 levels group was 22.8 months (95% CI 16.9–28.7), significantly longer than 11.1 months (95% CI 7.1–15, P = 0.001)