Table 2.
Univariate logistic regression analysis was used to analyze the risk factors of CRN at different anatomical sites
| Risk factors | The proximal colon | The distal colon | The rectum | The multiple colorectal sites | |||||
|---|---|---|---|---|---|---|---|---|---|
| Unadjusted OR (95% CI) | P value | Unadjusted OR (95% CI) | P value | Unadjusted OR (95% CI) | P value | Unadjusted OR (95% CI) | P value | ||
| Sex | |||||||||
| Female | Reference | Reference | Reference | Reference | |||||
| Male | 1.591 (1.485, 1.7032) | < 0.001 | 1.989 (1.881, 2.103) | < 0.001 | 1.685 (1.569, 1.809) | < 0.001 | 2.707 (2.564, 2.858) | < 0.001 | |
| Age (years) | |||||||||
| 40–50 | Reference | Reference | Reference | Reference | |||||
| 51–60 | 1.700 (1.463, 1.976) | < 0.001 | 1.628 (1.451, 1.826) | < 0.001 | 1.280 (1.100, 1.491) | 0.001 | 1.824 (1.588, 2.094) | < 0.001 | |
| 61–70 | 1.986 (1.718, 2.297) | < 0.001 | 1.789 (1.601, 2.000) | < 0.001 | 1.782 (1.542, 2.058) | < 0.001 | 3.559 (3.121, 4.059) | < 0.001 | |
| Greater than 70 | 2.060 (1.753, 2.420) | < 0.001 | 1.658 (1.460, 1.883) | < 0.001 | 2.165 (1.847, 2.538) | < 0.001 | 5.056 (4.399, 5.811) | < 0.001 | |
| BMI (kg/m2) | |||||||||
| Less than 23 | Reference | Reference | Reference | Reference | |||||
| 23–27.5 | 1.240 (1.145, 1.342) | < 0.001 | 1.197 (1.123, 1.276) | < 0.001 | 1.171 (1.080, 1.271) | < 0.001 | 1.385 (1.301, 1.475) | < 0.001 | |
| Greater than 27.5 | 1.360 (1.228, 1.507) | < 0.001 | 1.384 (1.275, 1.502) | < 0.001 | 1.209 (1.086, 1.346) | 0.001 | 1.815 (1.679, 1.962) | < 0.001 | |
| Smoking status | |||||||||
| Never | Reference | Reference | Reference | Reference | |||||
| Present or past | 1.242 (1.141, 1.352) | < 0.001 | 1.8776 (1.759, 2.001) | < 0.001 | 1.598 (1.470, 1.738) | < 0.001 | 2.301 (2.166, 2.444) | < 0.001 | |
| Alcohol intake | |||||||||
| Never or occasional | Reference | Reference | Reference | Reference | |||||
| Weekly or daily | 1.365 (1.214, 1.535) | < 0.001 | 1.772 (1.619, 1.939) | < 0.001 | 1.578 (1.405, 1.773) | < 0.001 | 2.383 (2.197, 2.585) | < 0.001 | |
| Family history of CRC | |||||||||
| No | Reference | Reference | Reference | Reference | |||||
| Yes | 1.131 (1.002, 1.277) | 0.046 | 1.009 (0.911, 1.117) | 0.863 | 1.003 (0.879, 1.144) | 0.967 | 1.074 (0.976, 1.181) | 0.143 | |
Family history of colorectal cancer was defined only in first-degree relatives
*CRN colorectal neoplasms, CRC colorectal cancer, BMI body mass index, OR odds ratio, CI confidence interval