Table 1.
Frequency of chromosomal aberrations induced in mouse bone marrow cells after treatment with vinblastine
| Treatment and doses | Total abnormal metaphases | No and (%) of metaphases with different types of chromosome aberrations | |||
|---|---|---|---|---|---|
| No | Mean(%) ± SE | Gap | Fragment and/or Break | Polyploidy | |
| I. Control (Non-treated) | 16 | 3.20 ± 0.37a | 7(1.40) | 9(1.80) | – |
| II. Vinblastine a-single dose | |||||
| 3 mg/kg | 32 | 6.40 ± 0.60b | 6(1.20) | 10(2.0) | 16(3.20) |
| 4.5 mg/kg | 41 | 8.20 ± 0.58b,c | 5(1.0) | 12(2.40) | 24(4.80) |
| 6 mg/kg | 51 | 10.20 ± 0.37c,d | 6(1.20) | 20(4.0) | 25(5.0) |
| 10 mg /kg | 60 | 12.0 ± 0.95d,e | 8(1.60) | 13(2.60) | 39(7.80) |
| b-3 successive dose treatment | |||||
| 3 mg/kg | 65 | 13.0 ± 0.95e | 8(1.60) | 12(2.40) | 45(9.0) |
| 4.5 mg/kg | 83 | 16.60 ± 0.93f | 11(2.20) | 22(4.40) | 50(10.0) |
| 6 mg/kg | 97 | 19.40 ± 0.56g | 14(2.80) | 25(5.0) | 58(11.60) |
A total of 500 cells were analyzed (five mice per group; 100 cells/mouse). One way ANOVA–Tukey’s multiple comparisons test was used. The values having different superscript letters in each column are significantly different from one another