. 2022 Nov 17;50(2):1059–1068. doi: 10.1007/s11033-022-08061-1

Table 2.

DNA fragmentation in spleen cells and comet analysis in the testes of male mice exposed to different doses of vinblastine

Treatment and doses	DNA Fragmentation % in spleen (Mean ± SE)	No. of cells with comets in testes	Class*				DNA damaged cells % (Mean ± SE)
Treatment and doses	DNA Fragmentation % in spleen (Mean ± SE)	No. of cells with comets in testes	0	1	2	3	DNA damaged cells % (Mean ± SE)
(−ve) control	9.5 ± 0.71^a	36	464	25	11	0	7.21 ± 1.07^a
Vinblastine 3 mg	10.2 ± 0.49^a,b	39	461	23	16	0	7.83 ± 0.93^b
4.5 mg	12.4 ± 0.47^c	51	449	28	17	6	10.24 ± 1.24^c
6 mg	18.6 ± 0.67^c,d	83	417	31	28	24	16.61 ± 1.50^c,d
10 mg	24.2 ± 0.88^d	107	393	35	31	41	21.43 ± 1.21^d

A total of 500 cells were analyzed for comets (five mice per group; 100 cells/mouse). *: Class 0 = no tail; 1 = tail length < diameter of nucleus; 2 = tail length between 1 × , and 2 × the diameter of nucleus; and 3 = tail length > 2 × the diameter of nucleus. Data are presented as Mean ± SE. Means with different superscripts (^a,b,c,d) between groups in the same column are significantly different at P < 0.05