Table 3.
Frequency of chromosomal aberrations induced in mouse spermatocytes after treatment with vinblastine
| Treatment and doses | Total abnormal metaphases | No and (%) of metaphases with different types of chromosome aberration | ||||||
|---|---|---|---|---|---|---|---|---|
| No | Mean(%) ± SE | X–Y univalent | Autosomal univalent | X–y u + A-u | Fragment and/or Break | Chain IV | Polyp | |
| I. Control (Non-treated) | 19 | 3.80 ± 0.37a | 17(3.40) | 2(0.40) | – | – | – | – |
| II. Vinblastine a-Single dose | ||||||||
| 3 mg/kg | 40 | 8.0 ± 0.77b | 25(5.0) | 12(2.40) | – | 1(0.20) | – | 2(0.40) |
| 4.5 mg/kg | 44 | 8.80 ± 0.37b,c | 28(5.60) | 12(2.40) | – | 1(0.20) | – | 3(0.60) |
| 6 mg/kg | 52 | 10.40 ± 0.93c,d | 23(4.60) | 20(4.0) | 1(0.20) | 3(0.60) | 1(0.20) | 4(0.80) |
| 10 mg/kg | 66 | 13.20 ± 1.16e | 45(9.0) | 17(3.40) | 2(0.40) | 2(0.20) | – | – |
| b-3 successive dose treatment | ||||||||
| 3 mg/kg | 51 | 10.20 ± 0.86b,c,d | 27(5.40) | 18(3.60) | – | 4(0.40) | 1(0.20) | 1(1.0) |
| 4.5 mg/kg | 55 | 11.0 ± 0.83c,d,e | 41(8.20) | 8(1.60) | – | 5(1.0) | – | 1(1.0) |
| 6 mg/kg | 61 | 12.20 ± 0.37d,e | 30(6.0) | 18(3.60) | – | 6(1.20) | – | 7(1.40) |
A total of 500 cells were analyzed (five mice per group; 100 cells/mouse). X–Y u X–Y univalent, A-u Autosomal univalent, Polyp Polyploidy. One way ANOVA–Tukey’s multiple comparisons test was used. The values having different superscript letters in each column are significantly different from one another