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. 2022 Nov 14;75(1):99–118. doi: 10.1007/s43440-022-00428-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Effects of acute WAY 161503 (WAY; 0.3–3 mg/kg, ip, a), RO 60-0175 (RO; 0.3–3 mg/kg, ip, b) and mirtazapine (MIR, 2.5–20 mg/kg, ip, c) or the corresponding vehicle (VEH) treatment on the cocaine-induced (COC, 10 mg/kg, ip) reinstatement of cocaine-seeking behavior in the bulbectomized (OBX, right panels) and SHAM-operated rats (SHAM, left panels). The number of active and inactive lever presses is expressed as the means (± SEM) of the data from 6 to 10 rats/group. The statistical analyses were done with two-way ANOVA with post hoc Newman–Keuls test. ***p < 0.001 versus extinction (EXT); ^^p < 0.01, ^^^p < 0.01 versus VEH + COC; ⁺⁺⁺p < 0.001 versus cocaine self-administration (SA)