Fig. 6.

Effects of repeated WAY 161503 (WAY, 1 mg/kg, ip; a), RO 60-0175 (RO, 1 mg/kg, ip; b), mirtazapine (MIR, 10 mg/kg, ip; c) or corresponding vehicle (VEH) treatment during extinction training on the reinstatement of the cocaine-seeking behavior. MIR (10 mg/kg, ip), WAY (1 mg/kg, ip), RO (1 mg/kg, ip), or VEH were injected daily during the extinction training in the bulbectomized (OBX) and SHAM-operated control rats. The reinstatement of the cocaine-seeking behavior was initiated using the cue or cocaine (10 mg/kg, ip). The number of active and inactive lever presses is expressed as the group means (± SEM) from 6 to 11 rats/group. The statistical analyses were done with three-way ANOVA followed by post hoc Newman–Keuls test. **p < 0.01, ***p < 0.001 versus corresponding group during extinction; ^^p < 0.01, ^^^p < 0.001 versus corresponding group treated with VEH