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. 2022 Dec 10;149(1):271–280. doi: 10.1007/s00432-022-04518-9

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Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — SC144 suppresses IL-6- and OSM-induced STAT3^Y705 phosphorylation in L3.6pl human pancreatic cancer cells. Representative Western blots (a) show that SC144 inhibited IL-6-induced STAT3^Y705 phosphorylation in L3.6pl cells in a dose-dependent manner. Densitometry revealed that this inhibition was significant after 24 h of treatment (b) (n = 3–8). SC144 inhibited OSM-induced STAT3^Y705 phosphorylation in L3.6pl cells in a dose-dependent manner (c) which was significant after six hours of treatment (d) (n = 4–5); *p < 0.05 versus IL-6, **p < 0.01, ***p < 0.001 versus OSM; ANOVA with Bonferroni-corrected post hoc tests