Skip to main content
. 2023 Jan 30;6(4):e202301924. doi: 10.26508/lsa.202301924

Figure 2. Inflammation-induced Il7 down-regulation and impact on emergency myelopoiesis.

Figure 2.

(A) Il7-GFP expression on gated bone marrow MSCs in mice injected i.p. with CFA (red) or saline (blue) for 5 d. (B) Il7-GFP Geo. mean in gated Lepr+ MSCs. (C) Number of Lepr+ MSCs in bone marrow. (D, E, F) Mice immunized with CFA i.p. and pretreated with the IL-7/aIL-7 cytokine/antibody complex (1.5/15 μg, respectively, clone M25) i.v. (D) Developing B-cell subsets in bone marrow. (E, F) Myeloid cell subsets in bone marrow (E) and spleen (F). Bars represent the average, and circles depict individual mice. *P < 0.05; **P < 0.005; ***P < 0.0005; and ****P < 0.00005 by an unpaired t test. Data in all panels are representative of two experiments.