Table 2.

Univariate and multivariate cox regression analysis

Analysis		Univariate			Multivariate
Covariate		HR	95% CI	p value	HR	95% CI	p value
Age	≥ 70 years	0.8	0.7–1.0	0.060
AFP	> 400 ng/mL	1.0	0.8–1.2	0.940
Albumin	< 35 g/L	2.0	1.7–2.4	< 0.001	1.9	1.5–2.3	< 0.001
Bilirubin	≥ 1.2 mg/dL	1.8	1.5–2.1	< 0.001	1.6	1.3–2.0	< 0.001
AST level	> 31 U/L	1.5	1.1–2.0	0.011	1.3	0.9–1.9	0.148
ALT level	≥ 35 U/L	1.1	0.9–1.3	0.570
INR level	> 1.2	1.3	1.1–1.6	0.003	1.0	0.8–1.3	0.997
Platelet count	< 150/nL	1.1	0.9–1.3	0.470
Tumor number	≥ 2	1.4	1.2–1.7	< 0.001	1.3	1.0–1.6	0.027
Max. lesion size	> 5.0 cm	1.4	1.2–1.7	< 0.001	1.7	1.4–2.0	< 0.001
BMD	< 114 HU	1.4	1.2–1.7	< 0.001	1.7	1.4–2.1	< 0.001

HR, hazard ratio; CI, confidence interval; AFP, alpha fetoprotein; AST, aspartate aminotransferase; ALT, alanine aminotransferase; BMD, bone mineral density