Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Jan 18;13:1109938. doi: 10.3389/fimmu.2022.1109938

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2023 Zhan, Li, Xu, Xiao and Bai

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Non-canonical and alternative inflammasome. Non-canonical inflammasome activation is triggered by caspase-4/5/11 activation upon recognition of intracellular LPS, followed by cleavage of GSDMD and subsequent pyroptosis, causing the potassium efflux, which then induces canonical NLRP3 inflammasome. The alternative NLRP3 inflammasome activation refers to the signal 1 only inflammasome response. In monocytes, TLR ligands alone trigger IL-1β secretion via TLR4-TRIF-RIPK1-FADD-CASP8 signaling upstream of NLRP3.