Figure 4.

Schematic illustration of targets of NLRP3 inflammasome inhibitors. Upon activation, NLRP3 oligomerizes through interactions between NACHT domains, then recruiting ASC via PYD-PYD interactions, assembled ASC recruits caspase-1, forming NLRP3 inflammasome. NKE7 binds to NLRP3; the interaction is necessary for NLRP3 inflammasome assembly. HSP90 is suggested to bind NLRP3 to promote its activation. K⁺ efflux, Ca²⁺ flux, Cl^- efflux, and mtROS production are upstream signaling events of NLRP3 activation. The targets of NLRP3 inflammasome inhibitors are shown.