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. 2023 Jan 18;14:1081612. doi: 10.3389/fphar.2023.1081612

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Copyright © 2023 Wu, Zhang, Liu, Wei, Li, Ma, Wang, Zhu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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H&E staining of the major organs in nude mice. After treatment of Saline, Pep-1@PDA NPs, Pep-1@PDA-TMZ NPs, and PDA-TMZ NPs Heart: The myocardial fibers are aligned (red circle); liver: No significant vacuolization (green circle), spleen: No obvious irregular shape of white pulp (yellow circle); lung: No obvious lymphocyte infifiltration (purple circle) and kidney: No obvious nephrotoxicity (bule circle).